The main aim of this article is to discuss the meaning and characteristics of Islamic civilisation and its global presence, particularly in the field of knowledge culture. Since both terms have been contested in contemporary scholarship to the point of their critics denying epistemic legitimacy to the concept of Islamic civilisation itself, the article devotes a lengthy discussion to defending its continuing validity and legitimacy. The most serious challenge comes from the concept of world-system developed by a number of Western thinkers, especially Immanuel Wallerstein. The article also explains the meaning of a civilisation’s global presence, which it argues exists at three different levels, namely territorial presence, cultural presence, and intellectual-spiritual presence. It argues that in the case of Islamic civilisation, its global presence exists at all the three levels. Since knowledge culture is presented as the very heart of Islamic civilisation given the fact that Islam claims to be the religion of knowledge, the article provides an introductory discussion of some important aspects of knowledge culture originating from Islamic civilisation that have become accepted through the West as integral parts of our common modern civilisation. The article concludes with suggestions for further studies and research on the theme of Islamic civilisation’s global presence but from new perspectives in the light of new realities in intercultural and inter-civilisational relations.